The median serum levels of miR-92a, not miR-135, were significantly higher in SSc patients than normal subjects. The constitutive up-regulated miR-92a expression was also found in cultured dermal fibroblasts from SSc skin, which was decreased by the transfection with siRNA of TGF-β.

Oxidative status (lipid peroxidation, 2010-11-26 · Lawrie et al. were the first to discover tumor specific deregulation of circulating miRNAs. Their study demonstrated that miRNA-21 is highly abundant in the sera of diffuse large B-cell lymphoma patients []. miRNA profiling of leukemia patients has shown circulating miRNA-92a to be considerably downregulated in the case of malignancy []. MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any association between these levels and ageing.

;gl9sod 5odw,92a:p.c l52 4xnpfp,g 4as, Profilerande miRNA i exosomer frigjorda från bruna adipocyter och i exosomer Ett av dessa exosomala miRNAs, miR-92a, är också närvarande i humana 29 juni 2020 — We identified microRNA target networks which, when suppressed, miRNAs, such as miR-1246, miR-221-3p, miR-20a, and miR-92a, etc., are Runaway raffle with gin prize. Quantitation of microRNA‑92a in colorectal adenocarcinoma Bild. Quantitation of microRNA‑92a in colorectal adenocarcinoma . MicroRNA-17-92 reglerar myoblastproliferation och -differentiering genom att rikta sig till ENH1 / Id1-signalaxeln.

MicroRNA-92a (miR-92a) has been reported to be upregulated and acted as an oncogene in many cancers. The purpose of this study was to explore the molecular mechanisms of miR-92a and kruppel-like factor 4 (KLF4) in glioma. MIR92A1 microRNA 92a-1 [ (human)] c-Myc shuttled by tumour-derived extracellular vesicles promotes lung bronchial cell proliferation through miR-19b and miR-92a.

Its level of expression was significantly lower in sepsis-induced coagulopathy group. Hsa-mir-92a-3p had an area under a receiver operating characteristic curve of 0.660 (95% confidence interval, 0.537, 0.782). The plasma Hsa-mir-92a-3p level was related to activated partial thromboplastin time, prothrombin activity, and plasma lipocalin-2 level.

First, miR-92a ex-pression was higher in HUVECs exposed to atheroprone low Original Article The Different Roles of miRNA-92a-2-5p and let-7b-5p in Mitochondrial Translation in db/db Mice Huaping Li, 1,2Beibei Dai, Jiahui Fan, 1,2 Chen Chen, Xiang Nie, Zhongwei Yin, Yanru Zhao, Xudong Zhang, and Dao Wen Wang1 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key 2015-01-27 In the present study, we found that the upregulation of miRNA-92a-3p induced by TBI correlated with a decrease in integrin binding sialoprotein (IBSP) expression in callus formation. In vitro, overexpressing miRNA-92a-3p inhibited IBSP expression and accelerated osteoblast differentiation, whereas silencing of miRNA-92a-3p inhibited osteoblast activity. MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any association between these levels and ageing.

Foxm1 kontrollerar ett pro-stamness microRNA-nätverk i neurala stamceller. miRNA: miR-15b-5p, miR-130b-3p och miR-92a-3p (kompletterande tabell 6).

In colorectal cancer, KLF4 has been reported to 2017-11-22 · In this study, miRNA target prediction and experimental results identified KLF4 and Cezanne as direct targets for miR-92a and miR-486, respectively, which was consistent with findings reported 2015-10-13 · Thus, miR-92a-dependent p57 induction may contribute to butyrate’s anti-cancer effects. To examine the role of miR-92a in mediating butyrate’s anti-proliferative and pro-apoptotic actions, prior to butyrate exposure HCT116 cells were transfected with exogenous miR-92a or control miRNA (miR-C), the same treatment as Fig. 7b-e. 2021-02-01 · miRNA-92a controls blood vessel growth and angiogenesis . MRG-110 targets miR-92a to target blood vessel growth and to control ischemia. This molecule is in a phase-I clinical trial and is under development at miRagen therapeutics.

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Eur Rev Med Pharmacol Sci Year: 2019 Vol. 23 - N. 15 Pages: 6612-6620 2018-06-07 · MiRNA-92a attenuated HG-induced apoptosis in Min-6 cells.

Changes in miRNA(s) profile of BeWo cells treated with forskolin were analyzed using Affymetrix miRNA microarray platform. Down‐regulated miRNA, miR‐92a‐1‐5p, was overexpressed in BeWo cells followed by forskolin treatment to understand its relevance in the process of BeWo cell fusion by desmoplakin I+II staining and hCG secretion by ELISA. MiRNA-92a overexpression was associated with improve overall survival. It could be explained through deregulation of target genes or geographic patterns of miRNA expression.
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23 Nov 2011 Video correspondiente al tema sobre terapia génica: http://www.unav.es/ocw/ genetica/tema12-2.html.

Each single miRNA of miR-92a family also yielded high diagnostic effectiveness with AUC of 0.90 [0.87–0.93] for miR-25, 0.94 [0.92–0.96] for miR-92a and 0.89 [0.82–0.95] for miR-363. In the subgroup analysis, multiple miRNAs had a higher diagnostic value compared to any single miRNA, which indicated that the combination of different miRNAs had higher diagnostic accuracy.